The Glutamatergic Synapse

In the mammalian central nervous system (CNS), glutamate is the predominant excitatory neurotransmitter. It is estimated that more than half of all synapses release glutamate and that almost all excitatory neurons in the CNS are glutamatergic.

Kainate receptor modulation of glutamatergic synaptic transmission in the CA2 region of the hippocampus - Falcón‐Moya - 2021 - Journal of Neurochemistry - Wiley Online Library

Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective - Li-Da Su, Na Wang, Junhai Han, Ying Shen, 2022

Figure 1, Schematic drawing of a glutamatergic synapse, with postsynaptic AMPA, NMDA, KA and metabotropic receptors - Jasper's Basic Mechanisms of the Epilepsies - NCBI Bookshelf

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Glutamatergic Synapse

KEGG PATHWAY: hsa04724

Unique transsynaptic complexes enable long-term synaptic plasticity in a synapse-specific manner

Glutamate and glutamate receptors in the vertebrate retina by Victoria Connaughton – Webvision

Neurotransmitters: Glutamate, What do glutamate neurotransmitters do?

GABA fluctuations driven by astrocytic Glu/ GABA exchange explain synaptic acuity

Tomas Malinauskas on X: Activating (glutamatergic) and inhibitory (GABAergic) synapses play key roles in regulating brain function. Glutamatergic synapses use glutamate, the the brain's excitatory neurotransmitter. 1/n / X

The role of transporters and synaptic cleft morphology in glutamate and GABA homeostasis and their effect on neuronal function